| Guinness Premiership |
| Sat 06 Sept 2008 | London Irish - Wasps | 26-14 |
|
| Sat 13 Sept 2008 | Leicester - London Irish | 24-22 (B) |
|
| Sat 20 Sept 2008 | London Irish - Bath | (B) 16-20 |
|
| Sat 27 Sept 2008 | Harlequins - London Irish | 27-28 |
|
| Wen 01 Oct 2008 | London Irish - Sale | (B) 28-6 |
|
| Sun 16 Nov 2008 | Newcastle - London Irish | 8-24 |
|
| Sun 23 Nov 2008 | London Irish - Saracens | 27-14 |
|
| Sun 30 Nov 2008 | Bristol - London Irish | 13-18 |
|
| Sat 20 Dec 2008 | London Irish - Gloucester | |
|
| Sat 27 Dec 2008 | Saracens - London Irish |  |
|
| Sat 03 Jan 2009 | London Irish - Newcastle | |
|
| Fri 09 Jan 2009 | Sale - London Irish | |
|
| Sat 14 Feb 2009 | London Irish - Harlequins | |
|
| Sat 21 Feb 2009 | Bath - London Irish | |
|
| Sun 01 Mar 2009 | London Irish - Leicester | |
|
| Sun 08 Mar 2009 | Wasps - London Irish | |
|
| Sun 15 Mar 2009 | London Irish - Worcester | |
|
| Sun 22 Mar 2009 | London Irish - Northampton | |
|
| Sat 28 Mar 2009 | Gloucester - London Irish | |
|
| Sat 04 Apr 2009 | London Irish - Bristol | |
|
| Sat 18 Apr 2009 | Northampton - London Irish | |
|
| Sat 25 Apr 2009 | Worcester - London Irish | |
|
